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Senescence: General Features and Current Progress on the Research
Zhang Ju1, Liu Siqi1*, Xu Ningzhi2*
1Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 101318, China; 2Cancer Institute and Cancer Hospital, Chinese
Abstract: Since senescence was defined in the early 1960s， research on this topic has made substantial
progress. The concept of “Hayflick limit” established from senescence research not only let us reveal important molecular
mechanisms of cell life at the cellular level， but also expand our understanding of the aging. In recent years，
more and more experimental results show that the senescence can effectively prevent the occurrence of cancer in
vivo， especially has obvious effect during early stage of cancer. Based on the knowledge over past half a century，
we would like to focus on the general futures， criteria and current progress of senescence in this review.
progress. The concept of “Hayflick limit” established from senescence research not only let us reveal important molecular
mechanisms of cell life at the cellular level， but also expand our understanding of the aging. In recent years，
more and more experimental results show that the senescence can effectively prevent the occurrence of cancer in
vivo， especially has obvious effect during early stage of cancer. Based on the knowledge over past half a century，
we would like to focus on the general futures， criteria and current progress of senescence in this review.
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