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RNAa: A New Contra-standard Model for ncRNA Regulating Gene Expression
Li-Tang Zhang1, Yi-Gang Wang1, Xin-Yuan Liu1,2*
1Xin Yuan Institute of Medicine and Biotechnology, College of Life Science, Zhejiang Science and Technology University, Hangzhou 310018, China; 2Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Science,
Abstract: RNA activation (RNAa) is a newly discovered model for non-coding RNA (ncRNA) regulating gene expression in contra-standard manner. The process is mediated by double-stranded RNA (dsRNA) which promotes the expression of homologous genes in a transcriptional level. As a newly discovered mechanism， RNAa differs greatly with traditional means in gene regulation， in which not only spatial interaction between dsRNA and it's target gene is involved， but also RNA interference (RNAi)-like sequence complement is dependent， that numerous targeting sites can be artificially selected to activate gene expression with comparatively high specificity. RNAa makes its targets beyond CpG islands and Alu sequences of promoter under control of methylation and acetylation state of histone H3 with long lasting activation than RNAi， which provides a new tool to treat cancer， metabolization and heredity diseases. Thereby， this article compared traditional ncRNA regulations with RNAa. Whereafter， reviewed relatively on RNAa's discovery， mechanism and it's future applications.
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