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The Mechanisms of TRAIL Resistance and the Novel Strategies for Reversing TRAIL Resistance
Lu Jiayan, Yang Yuanqin, Zhou Li, Wang Yigang*
School of Life Sciences, Xinyuan Institute of Medicine and Biotechnology, Zhejiang Sci-Tech University, Hangzhou 310018, China
Abstract: TNF-related apoptosis-inducing ligand (TRAIL) is an endogenous factor that can selectively induce tumor cell apoptosis without side effects to normal cells. Thus it is considered as a promising anti-cancer agent. However， present studies show that many human cancer cells are resistant to TRAIL， resulting in the arising bottleneck during the course of TRAIL clinical treatment. More and more evidence suggests that several key signaling pathway may be responsible for the development of resistance to TRAIL. Yet， it was reported that some natural medicines and small molecular inhibitors can partially restore the sensitive to TRAIL-induced apoptosis in cancer cells. This review mainly describes the molecular mechanisms of TRAIL resistance to tumor cells， and the underlying strategies for how to overcome efficiently TRAIL resistance to tumor cells.
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