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Histone Variant H2A.Z
Wu Baojiang1, Yu Hua3, Dai Yanfeng1,2, Guo Jitong1,2, Li Xihe1,2*
1Inner Mongolia Saikexing Reproductive Biotechnology Co., Ltd, Helingeer 011517, China; 2Research Center for Animal Genetic Resources of Mongolia Plateau, Inner Mongolia University, Hohhot 010021, China; 3Inner Mongolia In
Abstract: H2A.Z is one of histone variant of H2A and widely conserved histone variant that is implicated in protecting euchromatin from the spread of heterochromatin and involved in transcriptional regulation， antisilencing silencing and genome stability. H2A.Z may establish structurally distinct chromosomal domains and regulate chromatin structure and function. However， the mechanism and function of H2A.Z for chromatin is largely unknown. Histone variants H2A.Z and their post-translational modifications play an important role in the dynamics of chromatin structure and function. In this short review， we will discuss about histone variant H2A.Z.
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