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Semaphorins in Lung Development and Pulmonary Diseases
Luo Yingwan1, Lou Zhewei1, Wu Hongwei1, Wu Yajun1, Wang Qinquan1, Huang Zhihui2*
1Department of Clinic Medicine, Wenzhou Medical College, Wenzhou 325035, China; 2Department of Basic Medicine,Wenzhou Medical College, Wenzhou 325035, China
Abstract: Semaphorins are a large family of secreted and transmembrane signaling proteins that repel axons in the developing nervous system. Recent studies have shown that Semaphorins are involved in the development of lung and pulmonary diseases through regulating cell proliferation， adhesion， motility and apoptosis. This review focuses on the emerging roles of the Semaphorins in lung branching morphogenesis， angiogenesis and pulmonary diseases.
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