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Signaling Crosstalk in the Regulation of Epithelial-Mesenchymal Transition and Cancer Stem-Like Cells Properties Acquisition
Zhang Ting1, Cui Ge2*, Shao Shengwen1, Ye Jiahui1, Huang Bin1, Pan Zhen1
1Huzhou Teachers College Medical School, Huzhou 313000, China; 2Affiliated Hospital of Huzhou Teachers College, Huzhou 313000, China
Abstract: Epithelial-mesenchymal transition (EMT) is an important biological process that epithelial tumor cells can obtain the ability of invasion and metastasis. Cancer stem-like cells (CSLCs)/tumor-initiating cells (TICs) play a key role in tumorigenesis， tumor invasion， metastasis and recurrence. In recent years， it was found that EMT had a close correlation with the acquisition of CSLCs properties， they promote tumorigenesis， tumor invasion and metastasis by complicated interaction through signaling crosstalk between TGF-β， Wnt/β-catenin， Notch， Hedgehog， FGF， PI3k/Akt and other signaling pathways. Understanding the functions and interactions of key molecules within the context of EMT/CSLCs signaling is critical to design targeted therapeutics.
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