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Progress on Protein Misfolding Cyclic Amplification and Its Applications in the Detection of Prion Protein
Wang Haixia1, Shi Guoqing2, Liu Yixiao1, Wan Pengcheng2, Guan Feng1,3*
1College of Life Sciences, China Jiliang University, Hangzhou 310018, China; 2The Key Sheep Breeding and Reproduction Biotechnology Laboratory of Xinjiang Production and Construction Group, Shihezi 832000, China; 3China Ji
Abstract: Prion protein (PrP) is the pathogen of transmissible spongiform encephalopathy (TSE)， and its detection is the important diagnosis basis of the disease. In this paper， a new technology named protein misfolding cyclic amplification was reviewed， including the technical principles， methods， influence factors and applications in the prion diseases detection. The aim is to provide theoretical references for the detection of prion protein and the mechanism of the disease.
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