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Nrf2/ARE Signaling Pathway and Drug Resistance in Gastric Cancer
Geng Miao, Tang Xiuwen*
Department of Biochemistry and Genetics, Zhejiang University School of Medicine, Hangzhou 310058, China
Abstract: Gastric cancer is the second leading cause of cancer mortality worldwide. The major cause of treatment failure for gastric cancer is drug resistance to chemotherapy， which is currently one of the primary treatment options. Nrf2 as a key transcription factor， in response to oxidative stress， can bind to antioxidant response element ARE to regulate the expression of target genes of phase II detoxification enzymes， antioxidant enzymes and some drug transporter genes positively， which induce drug resistance of gastric cancer. In this review， we summarize Nrf2/ARE signaling pathway and drug resistance in gastric cancer.
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