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Function of PIP5KIC in Autophagosome Formation
Liu Mei1, Chen Lilian2, Zhang Shaojin3, Rong Yueguang1*
1School of Life Science, Tsinghua Univerdity, Beijing 100084, China; 2 School of Biology, China Agricultural University, Beijing 100083, China; 3Colledge of Animal Science and Techology, Huazhong Agricultural University, W
Abstract: Autophagy is a conserved lysosome-dependent degradative pathway in eukaryotes. During autophagy， autophagosomes engulf and deliver the accumulated proteins and damaged organelles to lysosomes for degradation. In our study， we found that type I phosphatidylinositol 4-phosphate 5-kinase isoform C (PIP5KIC) is involved in autophagosome formation. In mammalian cells， omegasome morphology is abnormal and autophagy level is decreased when PIP5KIC is knocked down. Similar phenotype was also found in yeast cells. The inactivation of Mss4， which is the homologue of type I phosphatidylinositol 4-phosphate 5-kinase in yeast， leads to the reduction in autophagy level. Based on these evidences， we concluded that PIP5KIC plays an important role in autophagosome formation.
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