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Promyelocytic Leukaemia Nuclear Bodies and Viral Infection
Wang Di1#, Zheng Yahong1#, Lei Ming1,2*
1College of Life Sciences, Northwest N&F University, Yangling 712100, China;2Key Laboratory of Agricultural Molecule Biology, Yangling 712100, China
Abstract: Promyelocytic leukaemia nuclear bodies (PML-NBs) are a kind of dynamic nuclear substructures in mammalian cells. PML-NBs have been demonstrated to participate in many important cellular activities， including DNA damage repair， senescence， apoptosis， gene expression， tumorigenesis and tumor suppression. Increasing evidences prove that PML-NBs are the targets of various viruses in infection. PML-NBs are involved in host antiviral defenses through mediating an intrinsic immune response against specific viruses or serving as the components of the cellular interferon pathway. In this review， taking several DNA and RNA viruses as examples， we summarize the interplay of PML-NBs with different viruses in infection to reveal the important roles of PMLNBs in antiviral defenses and cellular immune responses. Meanwhile， we propose that it will be helpful to study the functions of PML-NBs in viral infection using a new technological method named Single-virus Tracking.
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