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Effects of Caenorhabditis elegans dyn-1 on Lifespan and Fecundity
Cao Lei, Yang Yurong*
School of Life Science, Xiamen University, Xiamen 361005, China
Abstract: Cell polarity is crucial for the generation of cell diversity. Dynamin， a large GTPase， functions in both endocytosis and actin dynamics. Here， the C. elegans dynamin ortholog， DYN-1， maintains anterior polarity cues. dyn-1 was amplified from C. elegans cDNA by PCR and cloned into an expression vector and a RNA interference vector. The effects of dyn-1 on lifespan of N2， daf-2(e1370) and daf-16(e1038) were studied by RNAi. The lifespans of N2， daf-2(e1370) and daf-16(e1038) were shortened significantly. In this study， we also observed sterility and embryonic lethality in the dyn-1 RNAi-treated worms.
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