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Integrin Activation in T-cells via “Inside-out” Signaling
Xiao Jun1, Han Lei2, Li Chunyang2, Xu Xiaoyan2, Sheng Chun1*, Wang Hongyan2*
1College of Life and Environmental Science, Shanghai Normal University, Shanghai 200234, China; 2State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese A
Abstract: Integrins are transmembrane adhesion molecules that are critical for the migration of T cells to lymphoid organs and to sites of infection or inflammation. Integrins also play important role for conjugate formation between T-cell and antigen-presenting cell (APC). After T-cell receptor (TCR) is engaged by the MHC-peptide complex or after chemokine stimulation， many signaling proteins participate in “inside-out” signaling that result in integrin conformational changes or clustering at the cell surface. With increased affinity and avidity of integrins for their ligands， T-cells enhance adhesion ability to other lymphocytes. In the past several decades， many key signaling molecules and signaling complexes have been identified to regulate integrin activation. In this review， we summarize the role of several important signaling components， including ADAP， SKAP-55， RapL， Rap1， Talin and Kindlins in TCR induced “inside-out” signaling for integrin activation.
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