Home > Browse Issues > Vol.34 No.7
Progress on the Studies of ATP-dependent Lon Protease
Xia Lei#, Liu Yongzhang#, Yao Wei#, Li Zhen, Zhang Jiliang, Wu Zhi, Chen Lin, Lü Bin*
Attardi Institute of Mitochondrial Biomedicine, Zhejiang Key Laboratory of Medical Genetics, Department of Biology, School of Laboratory Medicine and Life Science, Wenzhou Medical College, Wenzhou 325035, China
Abstract: Lon， also known as protease La， is a homo-oligomeric ring-shaped ATP-dependent protease which is highly conserved among archaea， prokaryotes and eukaryotes. Lon is a member of the superfamily of ATPase (AAA+ ATPase) which is associated with diverse cellular activities. Since its first discovery， the Lon protease was found to play an important role in cellular homeostasis， mitochondrial protein quality control and metabolic regulation. In this review， we summarized recent advances in the studies of the ATP-dependent Lon protease. We focused on its structure， function in protein quality control， as well as its involvement in aging and diseases. Research achievements in model organisms will also be covered.
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