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The Pluripotent SoxB1 Family Genes
Hu Shengnan, Li Yiping*
State Key Laboratory of Cell Biology, Shanghai Key Laboratory for Molecular Andrology, Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Abstract: SoxB1 genes are group of transcriptional factors containing the HMG DNA binding domain. Till now the identified soxB1 family members include the Sox1， Sox2 and Sox3 in all vertebrate and Sox19a/Sox19b existing exclusively in teleost， which are involved in sexual determination， stem cell self-renewal/pluripotency maintenance and germ layer development. Forced expression of four transcriptional factors， Sox2， Oct4， c-Myc and Klf4 could successfully induce pluripotency stem cells from the somatic cell， which demonstrated the SoxB1 factors play an important role during the developmental process and greatly promoted its related basic research. In this review， we mainly focused on the current advance on SoxB1’s function.
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