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The Study on Autophagy and Its Significance in Cancer
Sun Yutao, Xu Lihong*
Department of Biochemistry and Genetic, Medical School of Zhejiang University, Hangzhou 310058, China
Abstract: Autophagy is a vacuolar process of cytoplasmic degradation by lysosome which widely exists in the eukaryotic cells. It is evolutionarily conserved from yeasts to mammalian cells and plays important roles in tolerating starvation and ischemia， cleaning the senescent organelles， eliminating bacteria and foreign matters， maintaining cellular activities and extending longevity. The present review focuses on recent progresses of the genesis and molecule mechanism of autophage as well as its regulation to tumor cells.
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