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The Effects of Ten Kinds of Phenylalanine Derivatives on Mouse Melanoma Cell Line B16
Chen Ran1,2, Yan Chunling1,2, Wang Binbin1,2, Yan Wenjuan1,2, Wang Shupei1,2, Xu Cunshuan1,2*
1College of Life Science, Henan Normal University, Xinxiang 453007, China; 2Key Laboratory for Cell Differentiation Regulation,Xinxiang 453007, China
Abstract: We studied the effects of 10 kinds of phenylalanine-bit derivatives on mouse melanoma cell line B16， which included cytotoxicity， induction of apoptosis and inhibition of cells into the colony. The 10 kinds of phenylalanine derivatives included Fp， Clp， Bp， Ip， Np， Sp， Pp， Ap， Mp， Cp. The results showed that the cytotoxicity of above phenylalanine derivatives to the B16 cell line was in sequence as follows: Pp， Fp， Mp， Ip， Sp， Ap， Bp. The cytotoxicity of Mp and Ip was similar， and the cytotoxicity of Sp and Bp was similar. The apoptosis-inducing activity for them were in sequence: Fp， Mp， Ip， while， the role of Mp and Ip was similar. The inhibition of cloneyforming unit arranged in a sequence: Pp， Fp， Ip， Mp， Sp， Bp， Np， Ap. The inhibition roles of Pp， Fp， Mp and Ip were similar， and that of Sp， Bp and Np were similar. Preliminarily cytotoxicity analysis showed that Fp， Mp， Ip induced B16 cell line apoptosis by cell nuclear and inhibited colony formation of cells.
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