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The Antagonism Regulation of Ubiquitination and SUMOylation for DEC1
Pan Hongming, Zhao Feng, Wu Huijian*
School of life Science and Technology, Dalian University of Technology, Dalian 116024, China
Abstract: DEC1 (differentiated embryo-chondrocyte expressed gene 1) is a clock protein which plays negative roles in regulation of circadian rhythm. Besides， DEC1 also takes important effect in metabolism and multi-tumor related signaling pathway. Moreover， post-translational modification is also an important regulation way to achieve the meticulous regulation of the protein functions. Recently， DEC1 could mainly be modified by two post-translational modifications–ubiquitination and SUMOylaiton. Although the processes of ubiquitination and SUMOylation are very similar， it is distinct in regulating the function of substrate proteins. Since the substrate target of both ubiquitination and SUMOylation is Lysine (Lys)， it is usually ubiquitination and SUMOylation that antagonistly regulate the functions of substrate protein. Therefore， this article aims to describe the antagonism regulation of ubiquitination and SUMOylation for DEC1， which gives new insights into the molecular mechanism of clock protein DEC1 in regulating multi-signaling pathway.
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