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Progress of Upstream Transcriptional Control Elements in Promoters of Skeletal Specific Genes
Zhao Dandan, Liu Congcong, Jia Mingyu, Yang Yue, Ye Feng, Yan Yunqin*
College of Life Science, Northeast Agriculture University, Harbin 150030, China
Abstract: The promoter of eukaryote， which is a short segment of DNA including core promoter and upstream transcriptional control element which regulates the strength and specificity of expression of genes， has been located at 5’ upstream of a gene. The specificity of a muscle specific gene is determined by the variety， the quantity and the sequence of upstream control elements on muscle specific promoters. The further understanding of the mechanism of a gene expression would be gained by further studying upstream control elements of muscle promoters， and would lay a theoretical foundation for the study of the improvement of muscle traits， the mechanism of proliferation and differentiation， and the gene therapy of disease. In this paper， we review the new discoveries in the area of studying the artificial synthetic promoter， which includes the molecule mechanism of the transcriptional control element on the muscle specific promoter， and the method or application of establishing the artificial synthetic promoter， and we discuss the urgent problem and the development prospect which would be solved in this area.
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