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Medical Application and Research Progress of 8-OHdG
Piao Enyi, Xu Lihong*
Department of Biochemistry and Genetics, School of Medicine, Zhejiang University, Hangzhou 310058, China
Abstract: Oxidative damages caused by oxidative stress are key factors for a variety of human injuries and diseases. 8-hydroxy-deoxyguanosine (8-OHdG)， a product of oxidative DNA damage， is widely applied in studying the mechanisms of oxidative damage in various diseases. A large number of studies have used 8-OHdG as an analytical indicator. The present paper reviews the recent development of 8-OHdG focusing on its effect mechanisms， detection methods as well as its application in hazard assessment of occupational and environmental exposure， in early diagnosis of disease， and in development of new drugs.
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