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The Investigation of Influence on Wnt Signaling Pathway by BATF2
Zheng Shuidi1, Wu Shuai2, Gui Jinghua1, Jia Xiaoyuan1, Zhang Kangjian2*
1Xin Yuan Institute of Medicine and Biotechnology, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China; 2Institute of Biochemistry and Cell Biology, Shanghai Institute of Biological Sciences, Chinese Academ
Abstract: Wnt signal pathway is highly conserved in different species throughout evolution， which plays a crucial role in tumor genesis and progression. BATF2 is a novel gene， which has shown the antitumor activity. But the relationship between Wnt pathway and BATF2 has not been clearly investigated. In this study， we revealed that BATF2 could influence the Wnt signaling pathway by luciferase report assay， Real-time PCR and Western blot. The overexpression of BATF2 could significantly reduce the TCF4/β-catenin transcriptional activity and the Wnt target genes expression， and downregulate the β-catenin in the nuclear. We hypothesized that the BATF2 reduced the Wnt signaling pathway through downregulating β-catenin in nuclear. The results provided an antitumor therapy through inhibit Wnt signaling pathway.
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