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DNA Methylation Modification and Stem Cells Differentiation
Sun Hongmei, Liu Linling, Cong Bo, Li Chunyi*
Institute of Special Wild Economic Animal and Plant Science Chinese Academy Agricultural Sciences, State Key Laboratory for Molecular Biology of Special Economic Animals, Jilin 132019, China
Abstract: Stem cells have the ability to self-renew and to differentiate into multiple different cell lineages. On one hand， it is because of the intercoordinations of endogenous transcription factors; on the other hand， epigenetics modification plays an important role. This paper reviewed the mechanism of DNA methylation， the feature of DNA methylation in mammalian stem cells and the DNA methylation modification during stem cell differentiation.
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