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Structure and Functions of Podosome in Osteoclast
Zhang Rong, Tian Zongcheng, Shang Peng∗
Key Laboratory for Space Bioscience and Biotechnology, Institute of Special Environmental Bophysics, School of Life Sciences,Northwestern Polytechnical University, Xi’an 710072, China
Abstract: Osteoclasts， multinucleated cell derived from hemopoietic stem cell， have bone absorption function which related to the integrality of F-actin. Studies demonstrated that podosome is the basic structure of F-actin in osteoclast. There are different patterns of podosome in the process of osteoclast differentiation. The forming process and integrality of podosome play crucial roles in the differentiation and bone absorption of osteoclast. Researches on podosome are helpful to understand the mechanism of bone resorption and to develop new therapeutics on bone diseases. In this paper， the structure， functions and the regulation mechanism of podosome were summarized.
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