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The Relationship of Notch-1 Signaling Pathway with Human Pap illaryCarcinoma of Thyroid
Yang Jingjin1, Yao Jun2, Shen Fengqing1, Chen Jiayu2, Yang Linjun3, Zhang Qiang3, Jing Xiaoyan3, Liang Yong2,3*
1The First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China; 2Medical School, Taizhou University,Taizhou 318000, China; 3Department of Oncologic Surgery, Taizhou Municipal Hospital, Taizhou 318000, China
Abstract: To approach the role of Notch-1 signaling pathway in the pathological development of human papillary carcinoma of thyroid， the expression levels of Notch-1， Hes1 and c-Myc mRNA were determined by Real Time PCR in 35 specimen of human papillary carcinoma of thyroid and 35 specimen of normal thyroid tissues around the nodular goiter. The Notch-1， NICD， Hes1 and c-Myc protein levels were determined by immunohistochemistry and Western blot. The expression of Notch-1 and Hes1 was significantly lower in the papillary carcinoma of thyroid than that in the normal thyroid tissues， but the expression of c-Myc was higher in the papillary carcinoma of thyroid. It suggested that Notch-1 and Hes1 may play a role in the pathological development of human papillary carcinoma of thyroid， and the expression of oncogene c-Myc may be unconcerned with the Notch-1 signaling pathway.
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