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Molecular Structural Basis of Microbial Halophilic Enzymes Related to Their Haloadaptation
Yan Song1,2, Chen Lei3, Lin Xiukun1*
1Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China;2School of Environmental Science and Engineering, Dalian Jiaotong University, Dalian 116028, China; 3
Abstract: Halophilic enzymes are isolated from microorganisms lived in the environment with high salt concentration， and this kind of enzyme only functions under high salt conditions. Halophilic enzymes have been considered to have a variety of industrial applications due to their tolerance on salt. Some halophilic enzymes have been cloned and purified and their molecular structural properties have been widely studied. In the present review， the recent progresses of molecular structural basis of halophilic enzymes related to halophilic characteristics are presented. Some questions and the prospects of future studies are also discussed. This review will contribute to a further understanding of the molecular basis of haloadaptation in halophilic enzymes and will be helpful for developing and identifying functional novel proteins.
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