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The Function of PTEN’s Protein Phosphatase Activity
Hao Lisen1, Liu Xiaojuan2, Zhang Xiaolan3*
1Department of Gastroenterology, the Affiliated Hospital of Hebei United University, Tangshan 063000, China; 2Department of Gastroenterology, the General Hospital of North China Oilfield Company, Renqiu 062552, China; 3Dep
Abstract: Phosphatase and tensin homolog deleted on chromosome ten (PTEN)， a tumor suppressor gene found to exhibit a dual specificity protein and lipid phosphatase activity， occurs deletion or dysfunction in a wide range of advanced cancers. Both lipid phosphatase activity and protein phosphatase activity of PTEN play an important role in regulating the biological behavior of tumor cell and maintaining normal cellular physiologic function. However， there are differences between lipid phosphatase activity and protein phosphatase activity in the focal point and mechanism of the function. And the function of its protein phosphatase activity is mainly to regulate the adhesion， migration and invasion of cell. In this article， the funcion of PTEN’s protein phosphatase activity and its mechanisms were briefly summarized for a better understanding of its role.
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