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Immunomodulatory Activities and Mechanisms of Polysaccharides on T/B Lymphocytes
Yi Yang1,2, Cao Yin3, Zhang Mingwei1*
1Bio-technological Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China; 2College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; 3Zhixing College,
Abstract: Many studies have shown their interests on the immunomodulation of natural polysaccharides. The activation of lymphocyte by polysaccharides has been widely evaluated as the enhancement of adaptive immune system. However， most of the studies just focus on the proliferation and cytokine/antibody secretion of lymphocyte without conclusive action mechanism. In the present papers， recent researches involved in the immunomodulatory polysaccharide of T/B lymphocytes were reviewed. It was concluded that polysaccharides could stimulate the activation of T/B cells simultaneously and selectively upregulate the function of T cell or B cell， the signaling pathway of T cell stimulated by polysaccharide were TCR/CD3→PTK→PI3-K→PKC/PLCγ→Ca2+→calcineurin →NFAT and TCR/CD3→PTK→MAPKs→AP-1， and that of B cell were TLR2/4→TRAF6→IKKc→NF- κB， TLR2/4→PTK→MAPKs→AP-1 and IgM/CD79→PTK→MAPKs→AP-1. Meanwhile， structure-function relationship of polysaccharide on lymphocyte was summarized.
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