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The Structure and Functions of Microtubule Actin Cross-linking Factor 1
Ai-Rong Qian, Li-Fang Hu, Peng Shang*
Key Laboratory for Space Biosciences & Biotechnology, Faculty of Life Sciences, Northwestern Polytechnical University, Xi抋n 710072, China
Abstract: Microtubule actin cross-linking factor 1 (MACF1) is a novel cytoskeletal linker protein and belongs to spectraplakin family. Structurally， MACF1 contains 3 domains， namely an N-terminal domain， a rod domain and a C-terminal domain. MACF1 takes an important role in associating with both actin microfilaments and microtubules and participating in signal transduction， protein transportation， embryonic development and disease occurrence. Recently the roles of MACF1 in regulating microtubule-actin dynamics have been paid much more attention. This review focuses on the latest research progress of the structure and functions of MACF1.
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