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The Use of Micro-CT in the Study of Bone Microarchitecture
Wang Weigang1,2, Liu Zhenze2, Li Jun3, Yan Huimin3*
1Department of Chemistry, Tongji University, Shanghai 200092, China; 2School of Life Science and Technology, Tongji University, Shanghai 200092, China; 3Shanghai Research Center for Model Organisms, Shanghai 201203, China
Abstract: OPG knockout mice were scanned by micro-CT. The reconstruction of the three-dimension mouse skeleton showed the widespread honeycomb shaped low density areas in OPG knockout mice. And we found that OPG knockout mice with lower level of BMD， SMI， Calibration of trabecular thickness， BV/TV， BS/BV， connectivity density and cortical bone thickness in comparison to wild-type littermates. But there was no any significant differences in the trabecular number， trabecular separation or DOA in both genotypes. The deletion of OPG in mice leads to osteoporosis. Micro-CT can be used to study bone architecture noninvasively in mice with some advantage over stereological measures.
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