Progress of PU.1-regulated Adipogenesis in Preadipocytes

Pang Weijun^1*, Wei Ning¹, Xiong Yan¹, Wang Ping¹, Tong Qiang²

¹Laboratory of Animal Fat Deposition and Muscle Development, Northwest A & F University, Yangling 712100, China;²Children’s Nutrition Research Center, Baylor College of Medicine, Houston 77030, USA

Abstract: PU.1 transcription factor is a member of conserved DNA-binding proteins which is called Ets family. As the common sequence GAGGAA is recognized in their DNA-binding region， it is named Ets binding region or PU.1 box. PU.1 mainly expresses in the hematopoietic system， such as myeloid cells and B lymphocytes， regulating the transcription of key myeloid genes to control the differentiation of the hematopoietic system. Global PU.1 deficiency in mouse leads to early embryonic death due to lack of fetal liver B lymphocytes and myeloid cells， indicating that PU.1 is a key transcription factor in control of life process. By now， effect of PU.1 on adipocyte adipogenesis and its mechanism have been rarely reported. The relationship between PU.1 and regulation of miRNAs， antisense RNA and C/EBPα/β-PPARγ pathway during adipocyte adipogenesis will be the focus of future research.

CSTR: 32200.14.cjcb.2011.12.0012