Home > Browse Issues > Vol.33 No.12
The Application of Photo Caging Group in Chemical Biology
Zhu Jieping1, Li Feng1, Li Yiming2*
1West Anhui Health Vocational College, Liuan 237005, China; 2Department of Chemistry, Tsinghua University,Beijing 100084, China
Abstract: The technology of photo-caging group is a novel Chemical-Biology approach， which was used to regulate the mechanism of life science. The term “caging” refers to installation of a photoremovable group on a biologically active molecule and encapsulates molecule in an inactive form. Irradiation with light removes the caging group and restores biological activity. This method provides unique possibilities for controlling bio-molecular function with high spatial and temporal resolution. This paper summarizes the structure and function of these lightsensitive compounds including nitrobenzyl， coumarin， quinoline， indole， nitrodibenzofuran. They adjust diverse biological processes selectively by caging physiological functional molecule such as neurotransmitter， calcium， protein， peptide， nucleotide and germ plasm.
CN
EN