Home > Browse Issues > Vol.33 No.12
Research Progress in Xenotropic Murine Leukemia Virus-Related Virus——A New Human Retrovirus
Wang Bin1#, Shen Xiaocao2#, Zhang Zhe3, Deng Gang3, Wang Dan1, Ye Jian1, Shen Xuebin1, Su Kunkai1,Chen Huan4*, Yang Jun4, Zhang Suzhan2
1Zhejiang-California International NanoSystems Institute, Zhejiang University, Hangzhou 310029, China; 2The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China; 3Ningbo Blood Cente,
Abstract: Xenotropic murine leukemia virus-related virus (XMRV) is a new gammaretrovirus that can infect humans. Retroviruses are enveloped， positive-sense RNA viruses that are associated with many diseases， such as neoplasias， immunodeficiencies， and neurological disorders. XMRV was originally identified in prostate cancer patients with a deficiency in the antiviral enzyme RNase L in 2006. The genome of XMRV is closely related to xenotropic murine leukemia virus (MLV). Recently， several independent groups have detected XMRV in prostate cancer and chronic fatigue syndrome patients， but the results vary greatly. The link between XMRV and human diseases has not been established. This paper presents and summarizes in detail the characteristics of XMRV， association of XMRV with human diseases， and potential mechanisms of XMRV pathophysiology. We also discuss the future research direction， such as the establishment of standard operation procedure and epidemiologic evidence of an association of XMRV with human diseases in large-scale studies.
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