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Progress in Studies on the Relationship between Autophagy and Cancer
Shi Feng, Wang Mingrong*
State Key Laboratory of Molecular Oncology, Cancer Institute (Hospital), Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, China
Abstract: Autophagy， a cellular self-degradation process， is crucial for metabolic stress， genomic integrity and cellular homeostasis. The levels of autophagic activity are different in diverse tumors. Autophagy plays important roles at different stages of tumorigenesis and cancer progression. In this review， we discussed the molecular mechanisms of autophagy and the implication of autophagy in human cancer.
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