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The Biological Function of A-kinase Anchor Protein 95
Hong-Zhen Wang*, Xiao-Guang Wang1
College of Life Science, Jilin Normal University, Siping 136000, China; 1School of Life Sciences, Changchun Teachers College, Changchun 130032, China
Abstract: A-kinase anchor protein 95 (AKAP95) is one of A-kinase anchor proteins (AKAPs). It can anchor protein kinase A (PKA) in the nucleus. Recent results also find that AKAP95 is invoved in many impotrant life process. It is involved in establishment and maintenance of chromosome condensation， regulation of gene expression， DNA replication and maintenance of mRNA stability. It is also involed in embryo development， apotopsis and cell cycle regulation. After briefly introduced what is PKA and AKAPs， this paper also reviewed the structure of AKAP95 and its cell cycle distribution and its newly founded important biological function.
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