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IL-1β Signaling and β Cell Function
Shan-Gang Zhao, Hong-Qiang Fei, Bin Zhao, Qin Wang*
Laboratory of Signal Transduction, College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
Abstract: Pancreatic islet β-cell dysfunction occurs in diabetes mellitus， leading to absolute or relative insulin deficiency， thus causing hyperglycemia. Recent studies show that there is a close relationship between diabetes mellitus and inflammation. Intra-islet inflammatory mediators seem to trigger a final pathway leading to β-cell death in diabetes. Interleukin-1β is a potent inflammatory cytokine， which plays a central role in β-cell dysfunction in diabetes mellitus via activating MAPK， NFκB or PKC signal pathway.
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