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Anticancer Effects of Histone Deacetylase Inhibitors
Lou Wenzhu, Sun Xueyan, Li Longzhu, Song Mengwan, Tao Jing, Guo Junming*
Department of Biochemistry, School of Medicine, Ningbo University, Ningbo 315211, China
Abstract: Histone acetyltransferase and histone deacetylase are enzymes that having opposite function. They modulate the level of acetylation of histone and regulate gene expression by addition or removal of acetyl groups to histone， respectively. They are associated with the occurrence of cancers. Recent researches found that by upregulating the level of histone acetylation and regulating the expression of target genes， histone deacetylase inhibitors inhibit proliferation， induce differentiation and apoptosis in tumor cells. The present paper reviewed their anti-tumor mechanisms in four points including inhibition of cell proliferation， induction of cell differentiation and apoptosis， and anti-angiogenesis. Finally， the classification of histone deacetylase inhibitors was also summarized.
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