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Targeting Leukemia Stem Cells as a Novel Strategy for Leukemia Treatment
Yan-Hong Zhang, Gong-Chu Li*
Xin Yuan Institute of Medicine and Biotechnology, College of Life Science, Zhejiang Sci-Tech University, Hangzhou 310018, China
Abstract: Leukemia stem cells (LSC) have been considered to be the origin of leukemia and the reason why leukemia develops and relapses. LSC have specific phenotypic characteristics， as well as capacities for self-renewal， proliferation， and differentiation. In recent years， targeting LSC has become a new strategy for therapy in leukemia. Researches are mainly focused on three aspects including LSC surface molecules， intracellular signaling pathways， and the interaction with micro-environmental elements. Further understanding on LSC may provide a variety of more effective novel therapeutic targets for the treatment of leukemia.
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