Home > Browse Issues > Vol.33 No.9
Antitumor Activity of the Polysaccharride from the Eggs of Strongylocentrotus Nudus (SEP) on S180 in vivo
Gao Yu, Yu Jian, Li Bing, Kang Di, Wang Hui, Dou Jie, Zhou Weidong, Xi Tao*, Zhou Changlin*
School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China
Abstract: This research is about the antitumor activity of the polysaccharride from the eggs of Strongylocentrotus Nudus (SEP) on S180 in vivo. MTT assay detected the inhibition effect of SEP on S180 in vitro. Model of S180-bearing mice was built to study the antitumor activity of SEP in vivo. Synergism effect of SEP on spleen lymphocyte proliferation induced by ConA/LPS. Besides， influences of SEP on NK cells and CTL activity were assayed. Carbon expurgation method was used to observe the function of mice mononuclear macrophages treated by SEP. The research found that SEP (16， 8， 4 mg/kg) could obviously inhibit the growth of S180 in vivo and increase the tumor-bearing mice’s spleen index and thymus index. SEP could stimulate spleen lymphocyte proliferation， increase NK cells and CTL activity. In addition， SEP could enhance the phagocytic function of mice mononuclear macrophages. So， SEP realizes it’s antitumor activity through immunomodulation.
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