Home > Browse Issues > Vol.33 No.9
Structural and Functional Studies of T Cell Receptor
Shi Xiaoshan, Li Lunyi, Guo Xingdong, Xu Chenqi*
State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Abstract: T cell receptor (TCR) is a critical immunoreceptor expressed on the T cell surface， which specifically recognizes peptide antigen-MHC (pMHC) complex and triggers T cell immune responses. Abnormal TCR function will cause autoimmunity or immunodeficiency. Unveiling TCR structure and function will help us to understand the molecular basis for immune response and might lead to better design of clinical therapies for T cell related human diseases. In this paper， we reviewed recent studies on TCR structure and function， including TCR classification， gene rearrangement， receptor assembly and structure， antigen recognition and activation mechanism.
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