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SUMOylation: An Important Post-translational Modification in Vivo
Xiang-Dong Li, Yang Shen, Ya-Feng Qiu, Zhi-Yong Ma*
Department of Veterinary Public Health, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200232, China
Abstract: Post-translational modification by the small ubiquitin-like modifer (SUMO) is emerging as a defining feature of eukaryotic cells. SUMO has been shown to covalently modify a large number of proteins， reversible modification by SUMO regulates nucleocytoplasmic translocalization， protein-DNA binding activity， protein-protein interaction， transcriptional regulation， DNA repair， and genome organization. SUMOylation also plays pivotal roles in human diseases such as cancer and neurodegenerative disorder， elucidating the biological significance of the protein SUMOylation and their roles in these diseases will provide powerful strategy for developing new therapeutic reagents.
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