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The Chaperonin Containing Tailless Complex Polypeptide 1 (CCT) and Its Relationship with the Cytoskeleton
Duan Fanglei1, Sun Xingwang1*, Cao Ling2
1Department of Pathology, Luzhou Medical College, Luzhou 646000, China;2Department of Nephrology, Luzhou Medical College Affiliated Hospital, Luzhou 646000, China
Abstract: CCT (the chaperonin containing tailless complex polypeptide 1) is a hetero-oligomeric protein widely existing in the cytoplasm， and is also the only chaperonin so far found in eukaryotic cytoplasm. In present opinion， about 15 percent of mammalian proteins folding need CCT participation. The most studied CCT substrates are actin and tubulin. It was found that abnormal CCT would lead to the changes of cytoskeletal proteins， and even affect the formation and depolymerization of cytoskeleton. It is inferred that a number of cytoskeleton-related diseases may be associated with CCT abnormalities.
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