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Progress and Application of Techniques for Investigating Cell Autophagy
Wang Haijie*, Tan Yuzhen
Department of Anatomy, Histology and Embryology, Shanghai Medical School of Fudan University, Shanghai 200032, China
Abstract: In physiological state， cells remove senescent organelles and abnormal long-lived proteins via autophagy to maintain homeostasis of their structures and functions. Autophagy is involved in embryonic development， immunological regulation and longevity. Significant increase of autophagic level is beneficial for cells to tolerate starvation， ischemia and apoptosis under pathological conditions. Autophagic dysfunction is implicated in some chronic infectious diseases， neurodegenerative diseases， lysosomal storage diseases and tumors. It is important to understand and apply reasonably the techniques monitoring autophagy for promoting investigation of cell autophagy. This review focuses on the techniques monitoring autophagy and their application in investigating autophagy.
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