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Network Regulation of Prostaglandin Pathway during Embryo Implantation
Zhao Zhen’ao1, Yang Zengming2*
1College of Life Science, Northeast Agricultural University, Harbin 150030, China;2College of Life Science, Xiamen University, Xiamen 361005, China
Abstract: Prostaglandin (PG) could rescue delayed implantation deficiencies in Cox-2-， cPLA2α- or Lpar3- deficient mice， respectively， suggesting that prostaglandin was important for implantation. PG could activate β-catenin through cAMP/PKA and PI3K/AKT， activate heparin-binding EGF-like growth factor (HB-EGF) pathway through matrix metalloproteinase cleavage and activate signal transducer and activator of transcription 3 (STAT3) through Src and IL-6. At the same time， COX-2 could be up-regulated by β-catenin， HB-EGF and STAT3. The genes in prostaglandin pathway could also form a positive feedback loop. The interactions among these pathways form a network， which may play important roles during embryo implantation.
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