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Progress in the p63 Regulatory Network Associated with Tumor
Li Yanhua, Zhang Shujuan, Xu Jin*
Department of Cell Biology, Harbin Medical University, Harbin 150081, China
Abstract: p63， a member of p53 family， encodes two classes of protein isoforms (TAp63/ΔNp63) that have adverse function and a variety of expression in squamous epithelium-derived cancers， closely associats with development of tumor. As an important transcription factor， p63 is a key node in forming a complexed regulatory network with its upstream and downstream genes. When the dynamic balance of ΔNp63-TAp63 changed， it will lead up to tumorigenesis and development. This paper summarizes the current progress including the expression regulation of p63， the action of p63 involving in cell proliferation， apoptosis， differentiation and cell adhesion and migration.
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