Home > Browse Issues > Vol.33 No.7
The Progress on Gene Copy Number Variations
Cheng Yuqiang, Guo Weixing, Cheng Shuqun*
Second Military Medical University, Shanghai 200438, China
Abstract: Copy number variations (CNVs) are structurally mutation regions of DNA which comprises deletion， insertion， recombination， and complex variation of DNA copy number. CNVs are detected not only in patients， but also in normal individuals. The existence of CNVs has tremendous enriched the difference in genome among random individuals and turned the concept of genetic disparity. Although there are lots of researches on CNVs， many of which are in primary stage. CNVs may play an important role in pathogenesis， but the mechanism that how CNVs cause diseases or evoke the alteration of genes is still unclear and to be proved. Here， we review the recent advancements of CNVs.
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