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Structure and Function of Microtubule-depolymerizing Kin-I Kinesins
Lei-Lei Jiang, Zuo-Ji Wu, Chun-Guang Wang*
Kin-I kinesins; microtubule; ATPase; depolymerization
Abstract: Kin-I kinesins are one important class of microtubule regulatory proteins which can depolymerize microtubules in an ATP-dependent manner. They have critical functions in neuronal development， spindle assembly and chromosome segregation. Over the past ten years， a big amount of studies have been done to understand Kin-I kinesins. Here， several aspects of Kin-I kinesins are reviewed briefly， including the structure， mechanism of microtubule depolymerization and their physiological functions.
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