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The Progress on Regulation of Microtubule by PP2A
Jing Liang, Li-Hong Xu*
Department of Biochemistry and Genetics, School of Medicine, Zhejiang University, Hangzhou 310058, China
Abstract: Microtubule is one of the important components of cytoskeleton， which exists in almost all eukaryotic cells and participates in a variety of essential cellular functions. PP2A is a major serine/threonine protein phosphatase in eukaryotic cells which is involved in many regulation pathways including microtubule-related process. The current paper presents the important role of PP2A on microtubule with focus on the post-translated modifications of tubulin， regulation of activity of molecular motors， dynamic balance of microtubule in cytokinesis and microtubule diseases.
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