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Specific Gene Silencing by Artificial MicroRNA
Qi-Zhen Chen, Zhi-Xian Zhang, Jia-Shu Cao*
Institute of Vegetable Science, Zhejiang University, Hangzhou 310029, China
Abstract: MicroRNAs are post-transcriptional regulators， composed by approximately 21 ribonucleic acid (RNA) molecules. By binding to complementary sequences of target genes， they can cause degradation of the mRNAs of target genes or inhibit their translation. MicroRNAs have been implicated in processes and pathways such as development， cell proliferation， apoptosis， metabolism and morphogenesis， and in diseases including cancer. This paper aimed to introduce achieving silencing of target gene by using artificial microRNAs， and applications of this method in life science.
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