Progress in RIP3 and Its Biological Function

Lei Shang^#, Kun Xiong^#, Hui Wang, Ju-Fang Huang^*

Department of Anatomy and Neurobiology, Xiangya Medical School, Central South University, Changsha 410013, China

Abstract: Receptor-interacting protein 3 (RIP3)， a member of the RIP kinase family， is characterized by the N-terminal Serine/Threonine kinase， RIP homotypic interaction motif (RHIM) and a unique C terminus lacks the death domain. It can promote programmed necrosis(necroptosis) in the absence of caspase activation. With the assist of RHIM， RIP3 can interact with RIP1， induce the phosphorylation of RIP1 and the activation of NF-κB and then participate in the cell survival. In this review， the structural properties of RIP3， the other cytokines which interacted with RIP3 and the biological functions of the RIP3 were summarized.

CSTR: 32200.14.cjcb.2011.04.0010