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Research Progression of FGFs/FGFRs System to Bone Regulation
Bao-Xin Li, Yu-Kun Li*
Third Hospital of Hebei Medical University, Second Department of Endocrinology, Shijiazhuang 050051, China
Abstract: FGFs and FGFRs constitute a system affect bone development and formation process， FGF combinates with FGFR to activate a variety of signaling pathways regulate cell growth， differentiation and apoptosis. Bone is an important target organ to FGF， studies have shown that FGFs/FGFRs system plays an important regulatory role for proliferation and differentiation of osteoblast， osteoclast and chondrocyte. This article reviews the research progression of FGFs/FGFRs system to bone regulation.
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