Home > Browse Issues > Vol.33 No.3
A modified Method to Induce Colitis Model by TNBS in C57/BL6 Mice Strain
Zhen-Ze Liu1, Hui-Min Yan2, Wei-Gang Wang1*
1School of Life Science and Technology, Tongji University, Shanghai 200092, China;2Shanghai Research Center for Model Organisms, Shanghai 201203, China
Abstract: Mice colitis model induced by 2，4，6-trinitrobenzene sulfonic acid is one of the most common method used for human IBD (inflammatory bowl disease) research. However， it is difficult to induce colitis in C57/ BL mice strain for its tolerance to TNBS. In this article， we introduced an effective method for inducing colitis model in C57/BL6 mice， and described the details of evaluation index for IBD degree. The establishment of the method for inducing colitis model by TNBS in C57/BL6 mice will make a significant contribution to research in IBD with genetic engineering mouse.
CN
EN